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9 Following the outbreak of COVID-19, researchers studied the potential of a link between ABO blood types and susceptibility to COVID-19 exposure. It is well known that individuals with particular ABO blood groups are at an increased risk of contracting several types of infections. One recent study indicated that the COVID-19 cell receptor is predicted to be angiotensin-converting enzyme 2 (ACE2). The spike glycoproteins interact with the viral envelope and the cytomembrane of the target cell. 7, 8 The receptor on the target cell is critical in determining how the virus enters the cell and which tissues are infected. 1 The virus’s morphology is similar to that of other coronaviruses, most notably SARS-CoV and MERS-CoV. 5 Multilabel factors including age, gender, comorbidities, economic status, and genetic makeup of the subject contribute to COVID-19 infection. 5 However, some patients quickly develop acute respiratory distress syndrome, shock, acidosis and coagulopathy, which can be fatal. 4 Patients with COVID-19 mostly present with symptoms including fatigue, fever and dry cough, followed by myalgia, anorexia, dyspnea, and more. In early March 2020, the first case of COVID-19 was confirmed in the Kingdom of Saudi Arabia, and since then, it has caused thousands of deaths.

3 The Kingdom of Saudi Arabia (KSA) is unique in that it serves as a hub for millions of international employees and pilgrims from all over the world. 2 By 9 December 2021, the World Health Organization (WHO) announced that the number of cases worldwide had reached 269,112,118 infected cases worldwide with a total of 550,136 reported cases in Saudi Arabia as daily reports and a total of 5,307,847deaths globally. 1 The World Health Organization (WHO) declared the novel coronavirus (COVID-19) outbreak a global pandemic on March 11, 2020. COVID-19 is caused by the novel SARS-CoV-2 coronavirus following initial infections in Wuhan, Hubei province, China, it has spread to nearly every country in the world, leading to a substantial number of deaths and an increasing economic burden.